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The "Grow" in Integrow

Rather than medical advice, this page provides valuable information about the wound healing processes. Discover the essential information about wound healing, so you may make educated decisions about your purchases. Explore the science behind wound care and take the first step towards better healing today! 

General Overview

Healing is Homeostasis

Homeostasis, or the equilibrium of physiological elements, is disturbed when you are injured. In other words, your body is thrown off balance and it tries to re-establish that equilibrium through healing. 

The ideal wound healing environment is one that is clean and moist. Clean means that there is a low bacterial population, and moist means that it is not dried out, but also not too wet where it is at the point of leaking. If a wound is scabbing over or crusting, then it is far too dry and will take a significantly longer time to heal as cells will not be able to migrate towards each other and close the wound. 

 

The different stages of wound healing and their respective cascades including physiological actions and actors. (Fernandez-Guarino et al.)

Figure 2: Healing cascade (Fernandez-Guarino et al.)

Difference in phases of normal (acute) and abnormal (chronic) wound healing (Gounden et al.)
Difference in phases of normal (acute) and abnormal (chronic) wound healing (Gounden et al.)

Figure 1. Difference in phases of normal (acute) and abnormal (chronic) wound healing (Gounden, Varshan, and Moganavelli Singh)

Inflammation is the same, where too much inflammation leads to a slow healing process or a chronic non-healing wound, but without the inflammatory process you would never heal. This is because the "inflammatory cascade" is the sequence of events that the body goes through to heal.

It is your job to keep your wound clean and moisturized! The best way to clean a wound is the tried and true method of using soap and water! One can use antiseptic solutions during dressing changes, but using soap and water in the shower is easy and extremely effective. Specifically, the suds from the soap are important as the foam and bubbles help to better surround and wash away dirt and bacteria. 

Once it is clean, a wound should be dressed with either a moist or dry dressing depending on the wound. We offer multiple effective options for dry and wet wounds at our store. Visit our store for a variety of wound care materials for cleaning and dressing wounds. We provide excellent dressings that are affordable and in use at top of the line wound care facilities! 

Ideal system for wound healing (Gounden, Varshan, and Moganavelli Singh).

Figure 3. Ideal system for wound healing (Gounden, Varshan, and Moganavelli Singh)

More in Depth...

     It is apparent in the literature and daily practice of wound care that wounds are able to heal faster based on different treatment methods. Excision of necrotic tissue and proper nutrition through diet have shown to increase rates of wound closure. These are two different methods of supporting the wound environment, but help to promote and accelerate healing. Another method is administration of various topicals that aid in the cleaning, debridement, or hydration of a wound. If there is a compromised blood supply to the area, this method becomes more important than oral nutrition. As the nutrients are not able to reach the wound through the bloodstream, the topical route becomes the main method of alleviating the stressors on the injured site. For example, large total body surface area (TBSA) patients are not able to circulate antibiotics (oral or IV route) to a wound bed due to the lack of blood supply resulting from the damaged capillary network. This leads to the need of proper cleaning and topical antimicrobial agents to dilute surface bacterial populations and inhibit further growth. However, once the damaged blood supply regrows and gains function, the wound will start to receive blood and in turn, oxygen and nutrients. 

 

     There are 4 stages of wound healing; 1) hemostasis 2) inflammation 3) proliferation and 4) remodeling, and this process of tissue and vessel growth is present in all wounds and is a result of the inflammatory cascade taking place after the onset of injury. Stage 2 is generally where we begin when speaking about wound care, unless there is a trauma where profuse and excessive bleeding occurs. In the inflammatory second stage, alongside the reagents that promote healing, there are the oxidative and negative influences of inflammation. These slow the growth of tissue as their cytotoxic qualities combat the positive action of the tissue growth factors. 

 

     If the cells make it to a living state and into the proliferative stage, they will need to a) migrate and b) stay alive. This calls for a hydrated environment with a low bacterial population. This can be maintained by cleaning, either with soap and water or antiseptic solutions, and by the use of topicals with antimicrobial agents. The common form of this topical is the household antibiotic ointment. Neosporin is the common, household triple antibiotic, but constant use over a long period of time has shown irritation in a large portion of the population. For this reason, clinicians will turn to a double or single antibiotic option or use non-anti-biotic containing products that are effective in decreasing bacterial growth. An example of this is silver sulfadiazine or Silvadene (SSD).

 

     The fourth stage is where remodeling occurs and this process lasts the longest. It is where scar formation and maturation occur and could last for years. There are surgical and topical treatments for this stage as well, including tissue excision or manipulation, injections, lasers, and scar gels and tapes. The efficacy for some treatments may be comparable, but the rate of improvement of these alternatives vary. While surgical intervention is the most effective and quickest route, it is far more costly and painful. Topical administration of scar gels or bleaching creams may take months to achieve texture and color goals or may not satisfy one's expectations, but they are considerably more affordable. 

References

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